Significance of Tissue Eosinophilia and Zinreich CT Scan Scoring in Nasal Polyposis

Abstract

INTRODUCTION:Chronic Rhinosinusitis with nasal polyp is chronic inflammatory condition of sinuses and nasal cavity characterized by the presence of benign and hyperplastic growths called nasal polyps. nasal tissue eosinophilia can predict the disease severity and prognosis of the disease.in this study an attempt has been made to find an association between nasal tissue eosinophilia and Zinreich CT scan scoring.

MATERIALS AND METHOD:The Observational study was conducted in a tertiary care centre involving 40 patients with nasal polyposis who underwent FESS All patients underwent  preoperative CT scan and modified Lund Mac Kay(Zinreich) scoring.Excised polyp tissue was sent for histopathological examination and eosinophil count was calculated per high power field. eosinophil count was categorized inti two groups:(=< 10 per high power field) and > 10 per high power field . We found that 15 patients had <= 10 E/hpf and 25 patients had > 10 E/hpf with mean CT scan scoring of 24.13+-18.9 and 37.8+-9.79 respectively.  In our study it was also found that 10 patients who had not undergone FESS previously had 0-5 E/hpf and 6 patients who had undergone FESS previously had 10 -15E/hpf indicating that tissue eosinophilia is significantly high in recurrent nasal polyps.

CONCLUSION:

There was moderate degree of correlation between nasal eosinophilia and CT scan scoring with p value< 0.0001. The no of eosinophils in histopathological specimen  is an important diagnostic modality to predict the recurrence of nasal polyps after FESS.