Clotrimazole Cream versus Ear Drops for Otomycosis: A Randomized Trial

Abstract

Introduction: Otomycosis is a superficial fungal infection of the external auditory canal with a global prevalence ranging from 9% to 30%. The increased use of antibiotic ear drops has contributed to its rising incidence. This study aimed to compare the effectiveness of clotrimazole cream and clotrimazole ear drops in managing otomycosis.

Materials and Methods: A prospective, randomized controlled trial was conducted on 300 patients diagnosed with otomycosis. Patients were divided into two groups: Group A received clotrimazole cream administered by ENT specialists, and Group B used clotrimazole ear drops as self-medication. All participants were followed for four weeks, with clinical evaluations performed weekly.
Results: After one week, Group A (clotrimazole cream) achieved a 98% resolution rate, while Group B (clotrimazole drops) achieved an 86% resolution rate. The cream group showed fewer treatment failures and recurrences compared to the drop group (p < 0.001).
Conclusion: Clotrimazole cream is more effective than ear drops in treating uncomplicated otomycosis. Its occlusive application and higher compliance may contribute to superior clinical outcomes.